Product Overview
MEVAC™ ND7 PLUS is an inactivated bivalent water-in-oil (W/O) emulsified vaccine for immunization against Newcastle Disease GII and GVII.
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MEVAC™ ND7 PLUS
Target Species
Chickens.
Newcastle Disease in Poultry Production
The Newcastle Disease Virus (NDV) classifications include pathotype categorization and genotype distinctions. The utilization of sequencing and phylogenetic analysis of the F gene enables the classification of NDV strains into varied genotypes. Genotypes I and II primarily represent primary vaccine strains, while the more virulent NDVs are clustered within Genotypes III to X. Intriguingly, in the 1990s the emergence of novel Genotypes VII and VIII expanded to Asia, South Africa, and parts of Europe; while Genotype VII NDV strains have been frequently reported since the 1990s from Europe, China, the Middle East, and South Africa.1,2,3,4
Inhalation and ingestion of virus-containing droplets are the main routes of infection. During the course of infection birds can also excrete large amounts of virus through their respiratory aerosols and contaminated feces.5
A robust biosecurity program addressing all risk factors involved is required to achieve effective control against all viral pathogens involved. This general prophylaxis should be based on flock isolation, facility sanitation, auditing and continued monitoring. Complementary to biosecurity, systematic vaccination of day-old chicks is crucial to build active immunity since early age against endemic Newcastle Disease virus across endemic geographies worldwide. Antigenic similarity is found among all NDV genotypes, and all viruses are expected to cross-protect against challenge with each other. Thus, immunological stimulation with live and inactivated NDV vaccines is the foundation to protect against virulent NDV (vNDV) circulating strains.6
Product Description
Composition (Before Inactivation)
- Inactivated Newcastle Disease Virus genotype II LaSota strain [ME/NDV3] ≥ 8.5 log10 EID50/dose.
- Inactivated recombinant Newcastle Disease Virus GVII [rgNDV1/ME.G7/2017] ≥ 8.5 log10 EID50/dose.
Indications
Active immunization of chickens to reduce clinical signs and mortality associated with Newcastle Disease.
Vaccination Program
Birds can be vaccinated from seven days of age onwards, as per advice from your poultry veterinarian. For optimal booster effects, the birds should be primed with live NDV vaccines.
Immunity
- Onset of immunity: 3 weeks after primary vaccination.
- Duration of immunity: until 6 weeks after single dose.
Dosage
The vaccine dose (0.5 mL/bird) should be administered subcutaneously in the lower part of the neck or intramuscularly in the thigh or breast muscles.
Withdrawals
Zero days.
Administration
Before use, the vaccine should be shaken well to ensure proper mixing. Sterile injection equipment should be used to avoid contamination.
- Subcutaneous injection: to be applied in the lower part of the neck. The needle should be inserted just under the skin in a direction away from the head and in a straight line with the neck.
- Intramuscular injection: to be administered in the breast muscles by inserting the needle with a 45° angle to avoid intraperitoneal injection.
Storage Precautions
- Store and transport refrigerated (+2°C to +8°C).
- Do not freeze.
- Store in a dry place protected from direct sunlight.
- Do not use this product after the expiry date.
- Shelf life after first opening the bottle: 3 hours.
Presentation
MEVAC™ ND7 PLUS is packed and presented in 500 mL (1000 doses) polyethylene terephthalate (PET) bottles.
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MEVAC™ ND7 PLUS product information she...
References
1. Abolnik C, Horner RF, Bisschop SP, Parker ME, Romito M, Viljoen GJ. A phylogenetic study of South African Newcastle disease virus strains isolated between 1990 and 2002 suggests epidemiological origins in the Far East. Arch Virol. 2004;149:603–619.
2. Herczeg J, Wehmann E, Bragg R, Travassos Dias PM, Hadjiev G, Werner O, Lomniczi B. Two novel genetic groups (VIIb and VIII) responsible for recent Newcastle disease outbreaks in Southern Africa, one (VIIb) of which reached Southern Europe. Arch Virol. 1999;144:2087–2099.
3. Ke GM, Liu HJ, Lin MY, Chen JH, Tsai SS, Chang PC. Molecular characterization of Newcastle disease viruses isolated from recent outbreaks in Taiwan. J Virol Methods. 2001;97:1–11.
4. Liu H, Wang Z, Wu Y, Zheng D, Sun C, Bi D, Zuo Y, Xu T. Molecular epidemiological analysis of Newcastle disease virus isolated in China in 2005. J Virol Methods. 2007;140:206–211.
5. Dimitrov et al (2019). Updated unified phylogenetic classification system and revised nomenclature for Newcastle disease virus. Infection, Genetics and Evolution. Volume 74, October 2019, 103917.
6. Sultan et al (2021). Efficacy of the Newcastle Disease Virus Genotype VII.1.1-Matched Vaccines in Commercial Broilers. Vaccines (Basel). 2022 Jan; 10(1): 29.
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