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MEVAC™ ND LASOTA

Product Overview

MEVAC™ ND LASOTA is a live-attenuated freeze-dried vaccine for immunization against Newcastle Disease.

Target Species

Chickens.

Respiratory Integrity Poultry

Newcastle Disease in Poultry Production

Respiratory diseases are among the most devastating diseases in poultry industry and are, in most cases, the result of more than one pathogen involved. Among several avian viruses with tropism of the respiratory tract, Newcastle disease virus (NDV) is one of the most important viruses of poultry worldwide.1

Due to the single stranded nature of the genome, the ND virus can evolve rapidly, leading to high genetic variability in circulating virus strains. NDV affects poultry birds of all ages and breeds, while other major respiratory pathogen, such as Infectious Bronchitis Virus (IBV), is more severe in young chicks.2

The immunology of domestic birds has been well studied and numerous vaccines have been developed against NDV. Most of these vaccines are either inactivated vaccines or live attenuated vaccines. Inactivated vaccines are designed to boost humoral response initially triggered with live vaccines.2

Using various strategies such as combination of live attenuated and inactivated vaccines will lead to effective programs that contribute to food security and the economic development of many countries on a global scale.2

Product Description

Composition

  • Live attenuated Newcastle Disease Virus LaSota [ME/NDV3] strain ≥ 6.5 log10 EID50/dose.

Indications

For active immunization of commercial chickens to reduce mortality and clinical signs associated with Newcastle Disease.

Vaccination Program

Birds can be vaccinated from first day of age onwards in endemic areas, as per advice from your poultry veterinarian.

Immunity

  • Onset of immunity: 2 weeks after primary vaccination.
  • Duration of immunity: until 6 weeks after single dose.

Considerations

Although the vaccine virus can spread to unvaccinated birds this does not induce any sign of disease in the flock.

Vaccine Preparation

  • Vaccine shall be reconstituted with sterile water free from disinfectant and/or antiseptic.
  • Shake the reconstituted lyophilisate until complete resuspension before administration.
  • Do not administer less than the recommended dosage.
  • Read instructions for appropriate dilution.

Withdrawals

Zero days.

Administration

The vaccine should be administered via the eye drop, spray, or drinking water routes. 

  • Eye drop: Reconstitute 1,000 doses into 3 to 5 ml of non-chlorinated drinking water and subsequently dilute it into 30-50 ml of non-chlorinated drinking water. Use a calibrated dropper to distribute 30-50 μl-drops. Place one drop of the vaccine solution on the eye of each bird, allow the drop to spread, and release the bird. 
  • Spray vaccination: Spray the vaccine solution above the birds using a spray capable of producing micro-droplets (mean diameter 80-100 μm). Make sure that birds are closely confined together during spraying. The ventilation system of the poultry house should be inoperative during the spray administration.
  • Drinking water: When using tap water, treat all water with skimmed milk powder at a rate of 2.5 g per liter to neutralize traces of chlorine. Distribute the vaccine solution at the time of use to birds. Birds should be deprived of water for two hours before vaccination.
MEVAC™ ND LASOTA

Storage Precautions

  • Store and transport refrigerated (+2°C to +8°C). 
  • Do not freeze.
  • Store in a dry place protected from direct sunlight.
  • Do not use this product after the expiry date.
  • Shelf life after first opening the bottle: 3 hours.

Presentation

MEVAC™ ND LASOTA is packed and presented in vials containing a lyophilisate pellet for reconstitution (1000, 2500, 5000 doses).

Download the Product Information Sheet

MEVAC™ ND LASOTA
Download

References

1. Malik YS, Patnayak DP, Goyal SM. Detection of three avian respiratory viruses by single-tube multiplex reverse transcription-polymerase chain reaction assay. J Vet Diagn Invest. 2004.

2. Ike et al 2021. Towards Improved Use of Vaccination in the Control of Infectious Bronchitis and Newcastle Disease in Poultry: Understanding the Immunological Mechanisms. Vaccines 2021, 9(1), 20; https://doi.org/10.3390/vaccines9010020

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The content on this site is intended for informational purposes only and is not intended to be a substitute for professional veterinary advice. Although the information on this site is accessible worldwide, not all products or services are available to all persons or in all geographic locations or jurisdictions. Certain statements, product labeling and claims may differ by geography or as required by local governmental regulations.