APHTHOVAC™ O

Foot and Mouth Disease in Ruminants

Foot-and-mouth disease (FMD) is a highly contagious viral disease of cloven-hoofed animals. The disease was initially described in the 16th century and was the first animal pathogen identified as a virus. The transboundary spread and significant economic impact associated to FMD, triggered authorities worldwide to deploy integrated control measures under the frame of National Control Programs.¹

Traditional FMD vaccines contain defined amounts of one or more chemically inactivated preparations of a seed virus strain blended with a suitable adjuvant and excipients. According to WOAH, commercial FMD vaccines should comply with important criteria:

1. Formulated with sufficient antigen and appropriate adjuvant to have a minimum potency level of 3 PD50 [50% protective dose] 
2. Provide 6 months of immunity after two initial vaccinations given 1-month apart 
3. Vaccine strains are selected based on antigenic relationship with circulating strains.²

APHTHOVAC™ O Product Details

Withdrawal

Zero days. 

Considerations

Some animals may develop swelling at the site of injection. These swellings will disappear within three days.

Dosage

• Cattle and buffalo: 2 mL per animal via subcutaneous injection.
• Sheep and goat: 1 mL per animals via subcutaneous injection.
• Pigs: 2 mL per animal via intramuscular injection. 

Administration

• Shake well before use.
• Allow the vaccine to reach room temperature (+20 to +25°C) before use.
• Use sterile injection equipment.
• Use the entire contents when first opened.
• The vaccine may occasionally separate into two layers on storage. This in no way affects its potency, but the vaccine should be shaken vigorously before and during use to ensure good emulsification.
• Do not use APHTHOVAC™ O if you notice critical irreversible separation of the emulsion

Presentation

APHTHOVAC™ O is packed and presented in 50 mL and 100 mL polyethylene terephthalate (PET) bottles.

References

1. Grubman and Baxt (2004). Foot-and-Mouth Disease. Clin Microbiol Rev. 2004 Apr; 17(2): 465–493. doi: 10.1128/CMR.17.2.465- 493.2004

2. WOAH (2021). Technical Disease Cards. OIE Science Department. Last updated January 2021

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