ButiShield™ - Butyrate for the Intestine and Beyond

ButiShield™ is an encapsulated low odor source of butyric acid designed for daily consumption. Providing a sustained release of >35% butyric acid, this unique ingredient offers science-based health benefits for the strength, health, and integrity of the intestinal wall, leading to health benefits beyond the intestine.

Science-Backed Benefits

Backed by scientific evidence, Butyrate operates as a main energy source for maintaining the vitality of intestinal cells and upholding the integrity of the intestinal barrier.^1-5 Additionally, Butyrate contributes to shaping a favorable microbiome and gastrointestinal environment.^6-9 Acting as a signaling molecule, it regulates a multitude of metabolic processes at the cellular level.^10-15 In essence, Butyrate offers:

• Support in shaping a healthy microbiome and maintaining a balanced gastrointestinal environment.^7-9
• Vital energy supply for sustaining the health of intestinal cells.^2-5
• Assistance in preserving the integrity of the intestinal barrier.^2-5
• Promotion of an overall healthy gastrointestinal environment.^6-9

Why Choose ButiShield?

• MicroPEARLS™ Technology: Our proprietary spray-freezing technology minimizes the typical unpleasant odor of butyric acid making it easier for manufacturers to use in production. MicroPEARLS also promotes a sustained release in the gastrointestinal (GI) tract for maximum benefit.
• 60 Years of Expertise: With over 60 years of expertise, Kemin has fine-tuned and mastered encapsulation technologies, elevating MicroPEARLS technology to the next level in human health.

Formulation Opportunities

Product Features

• Sustained and controlled release in the intestinal tract
• Low odor encapsulate for ease of formulation and handling
• Calcium
• No sodium added
• Non-GMO Project Verified
• Kosher, Halal, and suitable for vegetarians
• Allergen-free

How to Add ButiShield to Your Formulation

ButiShield can be seamlessly added to a wide range of formulations. Our Customer Laboratory Service team specializes in formulating with our ingredients to bring your innovative products to life.

Resources

Ready to Set Your Gut Health Product Apart with ButiShield?

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*These statements have not been evaluated by the US Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. The information on this webpage is a business-to-business information and not intended for the final consumer. Certain statements may not be applicable in all geographical regions. Product labeling and associated claims differs based upon government requirements and country or region specific information should also be considered when labeling or advertising to final consumers. This web page and its associated brochures and other documents do not constitute or provide scientific or medical advice, diagnosis, or treatment and are distributed without warranty of any kind, either expressly or implied. This web page, its title or contents and associated brochures and other documents do not in any way make recommendations for health or marketing claims by the reader. Country and region specific regulations should be considered in this regard. Each claim or statement about the effectiveness of Kemin products and/or each claim or statement comparing the effectiveness of Kemin products to the effectiveness of other products is expressly limited to the United States, unless otherwise disclosed on the Kemin websites.

References

1. Banasiewicz T, Domagalska D, Borycka-Kiciak K, Rydzewska G. Determination of butyric acid dosage based on clinical and experimental studies – a literature review. Gastroenterology Review/Przegląd Gastroenterologiczny. 2020;15(2):119-125. doi:10.5114/pg.2020.95556.
2. Donohoe, D.R., Garge, N., Zhang, X., Sun, W., O'Connell, T.M., Bunger, M.K. and Bultman, S.J., 2011. The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon. Cell metabolism, 13(5), pp.517-526.
3. Yan, H. and Ajuwon, K.M., 2017. Butyrate modifies intestinal barrier function in IPEC-J2 cells through a selective upregulation of tight junction proteins and activation of the Akt signaling pathway. PloS one, 12(6), p.e0179586.
4. Peng, L., Li, Z.R., Green, R.S., Holzman, I.R. and Lin, J., 2009. Butyrate enhances the intestinal barrier by facilitating tight junction assembly via activation of AMP-activated protein kinase in Caco-2 cell monolayers. The Journal of nutrition, 139(9), pp.1619-1625.
5. Bach Knudsen, K.E., Lærke, H.N., Hedemann, M.S., Nielsen, T.S., Ingerslev, A.K., Gundelund Nielsen, D.S., Theil, P.K., Purup, S., Hald, S., Schioldan, A.G. and Marco, M.L., 2018. Impact of diet-modulated butyrate production on intestinal barrier function and inflammation. Nutrients, 10(10), p.1499.
6. Facchin, S., Vitulo, N., Calgaro, M., Buda, A., Romualdi, C., Pohl, D., Perini, B., Lorenzon, G., Marinelli, C., D’Incà, R. and Sturniolo, G.C., 2020. Microbiota changes induced by microencapsulated sodium butyrate in patients with inflammatory bowel disease. Neurogastroenterology & Motility, 32(10), p.e13914.
7. Gao, F., Lv, Y.W., Long, J., Chen, J.M., He, J.M., Ruan, X.Z. and Zhu, H.B., 2019. Butyrate improves the metabolic disorder and gut microbiome dysbiosis in mice induced by a high-fat diet. Frontiers in Pharmacology, 10, p.1040.
8. Louis, P. and Flint, H.J., 2009. Diversity, metabolism and microbial ecology of butyrate-producing bacteria from the human large intestine. FEMS microbiology letters, 294(1), pp.1-8.
9. Vital, M., Karch, A. and Pieper, D.H., 2017. Colonic butyrate-producing communities in humans: an overview using omics data. Msystems, 2(6), pp.e00130-17.
10. Davie, J.R., 2003. Inhibition of histone deacetylase activity by butyrate. The Journal of nutrition, 133(7), pp.2485S-2493S.
11. Furusawa, Y., Obata, Y., Fukuda, S., Endo, T.A., Nakato, G., Takahashi, D., Nakanishi, Y., Uetake, C., Kato, K., Kato, T. and Takahashi, M., 2013. Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature, 504(7480), pp.446-450.
12. Inan, M.S., Rasoulpour, R.J., Yin, L., Hubbard, A.K., Rosenberg, D.W. and Giardina, C., 2000. The luminal short-chain fatty acid butyrate modulates NF-κB activity in a human colonic epithelial cell line. Gastroenterology, 118(4), pp.724-734.
13. Patnala, R., Arumugam, T.V., Gupta, N. and Dheen, S.T., 2017. HDAC inhibitor sodium butyrate-mediated epigenetic regulation enhances neuroprotective function of microglia during ischemic stroke. Molecular Neurobiology, 54(8), pp.6391-6411.
14. Zhang, M., Wang, Y., Zhao, X., Liu, C., Wang, B. and Zhou, J., 2021. Mechanistic basis and preliminary practice of butyric acid and butyrate sodium to mitigate gut inflammatory diseases: a comprehensive review. Nutrition Research, 95, pp.1-18.
15. Kasubuchi, M., Hasegawa, S., Hiramatsu, T., Ichimura, A. and Kimura, I., 2015. Dietary gut microbial metabolites, short-chain fatty acids, and host metabolic regulation. Nutrients, 7(4), pp.2839-2849
16. Sperber, A.D., Bangdiwala, S.I., Drossman, D.A., Ghoshal, U.C., Simren, M., Tack, J., Whitehead, W.E., Dumitrascu, D.L., Fang, X., Fukudo, S. and Kellow, J., 2021. Worldwide prevalence and burden of functional gastrointestinal disorders, results of Rome Foundation Global Study. Gastroenterology, 160(1), pp.99-114.
17. https://nutrition.org/most-americans-are-not-getting-enough-fiber-in-our-diets
18. Madison and Kiecolt-Glaser. Current opinion in behavioral sciences 28 (2019): 105-110.