PRALISUR™ – Algae-sourced Immune Support for Dogs

PRALISUR is a natural^* ingredient that contains more than 50% beta-1,3-glucans derived from dried algae. Beta-glucans are glucose polysaccharides naturally occurring in the cells of plants, cereals, and fungi. The beta-1,3-glucan sourced from algae has been shown to stimulate and activate the immune systems of animals.

Research on beta-glucan dates to the 1940s, and its efficacy and mechanism on the immune system has been well documented in a significant number of peer-reviewed studies. Beta-glucans have been used in livestock and aquaculture applications for many years, and can be found in a wide variety of human food and nutraceutical products for immune support.

How Beta-Glucan Works

Functional Benefits of Beta-Glucan in Dogs

In dogs, it has been shown that beta-1,3-glucan can:

• Help support a healthy immune system
• Support cytokine production involved in a healthy immune response¹
• Support the production of healthy white blood cells²
• Support the production of antibodies¹

Other potential functional benefits of beta-glucan in dogs have been demonstrated in various research publications as a supportive approach for atopic dermatitis,³ for inflammatory bowel disease⁴ and for steoarthritis.⁵

Beta-Glucan – Sources and Functions in the Body

Algae-sourced beta-glucans are unique in how they can support a dog’s natural defense system at the cellular level, in comparison to beta-glucan from other sources.⁶

Structural differences impact the function of beta-glucans in the body, as different sources have unique molecular structures. Among the various sources of beta-glucan, PRALISUR contains one of the highest concentrations of linear beta-1,3-glucan. PRALISUR is activated during the digestion process, which easily breaks down the protein-rich skin of algae to release (1,3) algae beta-glucans. After digestion, beta-1,3-glucans are absorbed in the small intestines, where they can support a healthy immune response.

The table below provides an overview on beta-glucan sources and their functions in the body.^7-10

Add PRALISUR to Your Pet Care Product

The Kemin Technical Service and Customer Laboratory Service (CLS) teams are your partners throughout the entire pet food manufacturing process. Our experienced team of scientists and ingredient specialists is ready to provide technical advice, vendor assurance and laboratory testing to meet your specifications.

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*Natural according to the Association of American Feed Control Officials (AAFCO) Official Publication definition of “Natural”.

References

1. Stuyven, E., et.al. 2010. Oral Administration of -1,3/1,6-Glucan to Dogs Temporally Changes Total and Antigen-Specific IgA and IgM. Clinical and Vaccine Immunology, Feb. 2010, p. 281–285

2. Kataoka, K., et. al.,2002. Activation of Macrophages by Linear (1,3)-D-Glucans. Journal of Biological Chemistry. V. 277, No. 39, Sept 27, pp. 36825–36831. http://www.jbc.org

3. Beynen, C. et. al., 2011. Dietary Beta-1,3/1,6-Glucans Reduce Clinical Signs of Canine Atopy. American Journal of Animal and Veterinary Sciences 6 (4): 146-152.

4. Rychlik, A., Nieradka, R., Kander, M., Nowicki, M., Wdowiak, M. and Kolodziejska-Sawerska, A. 2013. The Effectiveness of Natural and Synthetic Immunomodulators in the Treatment of Inflammatory Bowel Disease in Dogs. Acta Veterinaria Hungarica. 61(3): 297-308

5. Beynen, C., et. al.,2010. Influence of Dietary Beta-1,3/1,6- Glucans on Clinical Signs of Canine Osteoarthritis in a Double-Blind, Placebo-Controlled Trial. American Journal of Animal and Veterinary Sciences 5 (2): 97-101

6. Anderson, W., Satyaraj, E. and Kerr, W. 2008. Abstract from Nestle Purina Nutrition Forum 

7. Gupta, M., Abu-Ghannam, N., & Gallaghar, E. (2010). Barley for Brewing: Characteristic Changes during Malting, Brewing and Applications of its By-Products. Comprehensive Reviews in Food Science and Food Safety, 9(3), 318-328.

8. H. Marchessault, R., & Deslandes, Y. (1979). Fine structure of (1→3)-β-d-glucans: curdlan and paramylon (Vol. 75).

9. Lazaridou, A., Biliaderis, C. G., Micha-Screttas, M., & Steele, B. R. (2004). A comparative study on structure–function relations of mixed-linkage (1→3), (1→4) linear β-d-glucans. Food Hydrocolloids, 18(5), 837-855.

10. Manners, D. J., Masson, A. J., & Patterson, J. C. (1973). The structure of a beta-(1 leads to 3)-D-glucan from yeast cell walls. The Biochemical journal, 135(1), 19-30.