BetaVia™ Nature's Immune and Gut Promoter

BetaVia™ is a naturally sourced, algae-based beta glucan dietary ingredient that uniquely supports both the immune and gastrointestinal systems. Derived from a proprietary strain of Euglena gracilis algae¹, BetaVia offers diverse product forms suitable for various applications, including water dispersible options.

Science-Backed Benefits^2-24

BetaVia serves as a postbiotic, supporting both immune and gastrointestinal health. It aids in maintaining a robust immune system and a healthy respiratory tract while promoting digestive health. Additionally, BetaVia offers potential protection against oxidative stress, further enhancing its role in overall health support.

Why Choose BetaVia?

1. Label Friendly Beta Glucan: Crafted from non-GMO algae adhering to strict quality standards
2. Purity: BetaVia is available in two concentrations, >50% beta glucan and >95% beta glucan - the purest beta glucan available
3. Clinical Evidence: Supported by clinical studies showcasing dual benefits for immune and gastrointestinal (GI) health

Clinical Research Highlights

BetaVia employs a triple-action protection mechanism³, involving priming key immune cells, shaping the microbiome, and safeguarding intestinal barrier integrity. This approach enhances immune health by interacting with innate immune cells crucial for overall immune function, particularly vital given the significant immune system presence in the gut.

In a 90-day double-blind, placebo-controlled study³, BetaVia demonstrated effectiveness in reducing the likelihood and severity of upper respiratory tract infection (URTI) symptoms, yielding significant results compared to the placebo group. Participants experienced 70% fewer URTI symptoms, with a 3.3-day decrease in sick days and 10 fewer days with URTI symptoms during the trial period.

Patented Production Process

BetaVia's efficient fermentation process ensures quality and consistency, adhering to current Good Manufacturing Practices (cGMPs), setting it apart from other immune and gut health ingredients.

Formulation Opportunities

BetaVia serves as a stable and highly adaptable ingredient, seamlessly integrating into a wide array of formulations. Our Customer Laboratory Service team specializes in leveraging our ingredients to assist in bringing your products to life. Choose BetaVia for a natural, efficacious, and scientifically supported solution to enhance your immune and gut health formulations.

Resources

References

1. Euglena gracilis ATCC PTA-123017
2. Salminen, et al. Nat rev Gastroenterol Hepatol (2022). https://www.nature.com/articles/s41575-021-00440-6
3. Evans, M., et al., Effect of a Euglena gracilis Fermentate on Immune Function in Healthy, Active Adults: A Randomized, Double-Blind, Placebo-Controlled Trial.  Nutrients, 2019, 11(12), 2926
4. Kemin, BetaVia Complete can prime key cells in the innate immune system. KHTL-017-150.
5. KHTL-017-162 BetaVia Pure Can Prime Key Cell sin the Innate Immune system. KHTL-017-150.
6. KHTL-017-160 Paramylon Improves Antioxidant Status and Metabolic Health-TL-20-18529
7. KHTL-017-149 Characteristics and Prebiotic like Properties of BetaVia Complete
8. Kemin, Characteristics and prebiotic like properties of BetaVia Complete. KHTL-017-149.
9. Bhattad T, Koradiya A, Prakash G. Prebiotic activity of paramylon isolated from heterotrophically grown Euglena gracilis. Heliyon. 2022 Aug 27;7 (9): e07884. doi: 10.1016/j.heliyon.2022.e07884
10. Russo, R., et al. “Euglena gracilis paramylon activates human lymphocytes by upregulating pro-inflammatory factors.” Food Science & Nutrition 5.2 (2017): 205-214
11. Kondo, Y., et al. "Cytokine-related immunopotentiating activities of Paramylon, a β-(1→ 3)-D-glucan from Euglena gracilis." Journal of Pharmacobio-dynamics 15.11 (1992): 617-621.
12. Kankkunen, P., et al. "(1, 3)-β-Glucans activate both dectin-1 and NLRP3 inflammasome in human macrophages." The Journal of Immunology 184.11 (2010): 6335-6342
13. Brown, G.D., and Siamon G. Immune recognition: A new receptor for [beta]-glucans." Nature 413.6851 (2001): 36.
14. Brown, G.D., et al. "Dectin-1 is a major β-glucan receptor on macrophages. Journal of Experimental Medicine 196.3 (2002): 407-412.
15. Brown, G.D., et al. Dectin-1 mediates the biological effects of β-glucans." Journal of Experimental medicine 197.9 (2003): 1119-1124.
16. Goodridge, H.S. et al. "β‐glucan recognition by the innate immune system. Immunological reviews 230.1 (2009): 38-50.
17. KEMIN internal document: SD-18-00083
18. Ishibashi, Ken-ichi, et al. “Effects of Euglena gracilis EOD-1 ingestion on salivary IgA reactivity and health-related quality of life in humans.” Nutrients 11.5 (2019): 1144.
19. Nakashima, Ayaka, et al. “The alga Euglena gracilis stimulates Faecalibacterium in the gut and contributes to increased defecation.” Scientific reports 11.1 (2021): 1-8.
20. Nakashima, Ayaka, et al. “Effects of Euglena gracilis Intake on Mood and Autonomic Activity under Mental Workload, and Subjective Sleep Quality: A Randomized, Double-Blind, Placebo-Controlled Trial.” Nutrients 12.11 (2020): 3243.
21. Kawano, Takanori, et al. “Effect of Food Containing Paramylon Derived from Euglena gracilis EOD-1 on Fatigue in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Trail.” Nutrients 12.10 (2020): 3098.
22. SD-17-00243 Kemin Internal Document (Effect of 50%BG on the immune and intestinal health status of weaned piglets)
23. SD-9-21271 Kemin Internal Document (Effect of 50% BG on IgA in piglet feces)
24. TD-17-0322 Kemin Internal Document (Effect of 50% and 95% BG on gut and systemic immunity in mice)
25.  KHTL-017-159 BetaVia Complete Supports Gut Health after Induced Colitis in Mice
26.  Kemin Proprietary Data TD-20-6867
27. Vighi, G., Marcucci, F., Sensi, L., Di Cara, G., & Frati, F. (2008). Allergy and the gastrointestinal system. Clinical and experimental immunology, 153 Suppl 1(Suppl 1), 3–6. https://doi.org/10.1111/j.1365-2249.2008.03713.x
28. Patents granted a patent on beta 1,3 glucans for modulating immune function (US Patent 10,912,794).  This new patent joins a previously issued patent, US 9574217, on the production of immune modulation using algae from a proprietary strain of Euglena gracilis ATCC PTA-123017.
29. KHTLA-017-181 BetaViaTM helps to Maintain Health and Promote Gut Health by Supporting Intestinal Barrier Integrity
30. KHTLA-017-180 BetaViaTM A Natural New-Generation Postbiotic that works as both an Immune Gut Health Promoter
31. KHTLA-017-148 (TL-20-18591) Characteristics and Prebiotic like properties of BetaVia Complete